Ms Kercher, an exchange student from the University of Leeds, was murdered in Perugia, Italy on November 1, 2007. Ms Knox and former boyfriend Raffaele Sollecito were initially convicted for Ms Kercher’s murder before eventually being released.
In 2011, Ms Knox and Mr Sollecito had their conviction overturned following an appeal, before being retried and found guilty three years later.
They were eventually exonerated in 2015.
A local man, Rudy Guede, was then convicted of the murder after his DNA was found on the British girl’s body and in the room where she died.
In October, Ms Knox had her first child with husband Christopher Robin, and now says she finds herself thinking “oh my god, it could have been me” now that she is a mother herself.
Speaking on the American podcast Call Her Daddy, Ms Knox said she frequently thinks about her former roommate.
She told the programme: “I’m especially thinking about that now that I’ve had a daughter because like on the anniversary of her death for the past many, many years, 14 years.
“I’ve always sort of put myself in her shoes, and thinking like ‘oh my god, what must it have been like? What were her last moments ever as a person. Horrible, horrible moments. Thinking ‘oh my god, it could have been me’.
“And this year I couldn’t help but put myself in her mum’s shoes, and thinking ‘oh my god, if that happened to my baby’. What do you do?
“I can totally understand how her mum would have willingly taken her daughter’s place if she could, but she couldn’t.”
After the 14th anniversary of her roommates death, Ms Knox has shared she sent messages to Ms Kercher’s family seeking a relationship.
Asked if they had spoken, she said: “No, not yet. Not yet is my sort of position because like I know that it’s a complicated situation.
“I know that at least in the past like it’s unclear to me at this point how they feel about me.
“And I don’t want to like force a relationship on them if it’s traumatic for them. So I have sent messages to them through intermediaries telling them I want to have a relationship with you.
“I want to talk to you. And I’m waiting to see if that’s something that they want too.”
Speaking to the Daily Mail, Ms Knox said she, like Ms Kercher’s family, wants to know the truth behind her roommates murder.
She told the outlet: “I want the same thing that they want. I want to know the truth. I want to know what happened to Meredith.
“I want her to be recognised for who she was, and I want their suffering to be recognised for what it is. And I want them to get the closure that they deserve. I want that too.
“That’s why I have really complicated feelings about her killer, Rudy Guede, because I’ve spent time in prison now too. Because he’s out.”
Speaking earlier this month, Ms Knox said she faces an “ongoing struggle” to live with the public’s “made up version of herself”.
Speaking to BBC Radio 4’s Woman’s Hour on November 4, she said the story that captured global attention “became a morality tale about female sexuality”.
She said: “Meredith was pitched as this virginous Madonna character and I was portrayed as this sexually obsessed lustful uninhibited whore.
“I think that there was an incredible violation of my privacy. But also a capitalisation upon my identity that often had nothing to do with me.
“People vehemently stood for one side or the other and were unable… again there was the sense of confirmation bias you see what you want to see.”