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Police said they were called to Chippenham Road, Maida Vale, just after 9am to reports of a stabbing.
A woman was found with stab injuries and a man had been struck by a vehicle.
They were pronounced dead at the scene.
The Met Police has launched an investigation. No arrests have been made yet.
A number of road closures are in place.
In a statement, the force said: “Police were called at 9.01am on Monday, 24 January to reports of a stabbing in Chippenham Road, W9.
“Officers, London Ambulance Service and London Fire Brigade attended the scene.
“A woman was found at the scene with stab injuries.
“Officers also found a man at the location who had been struck by a vehicle.
“Both the man and the woman were pronounced dead at the scene.
“Officers are working to inform their families. Post-mortem examinations will be arranged in due course.
“There has been no arrest at this stage. Enquiries are under way to establish the circumstances. Roads are closed in the area.”
London Ambulance Service and London Fire Brigade also attended the incident.
A London Ambulance Service spokesperson said: “We were called at 9.02am today (24 January) to reports of an incident on Chippenham Road, W9.
“We sent a number of resources to the scene, including two ambulance crews, two clinical team leaders, an advanced paramedic, two tactical response units, a medic in a car, an incident response officer, and members of our hazardous area response team. We also dispatched by road London’s Air Ambulance.
“Despite our medics’ efforts, two people died at the scene.”
Anyone with information is asked to call police on 101 quoting ref 1496/24jan or Crimestoppers anonymously.
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